A Case of Malignant Mesothelioma with Abnormal CDKN2 Gene Accompanied by Malignant Melanoma.

概要

論文の詳細を見る
We treated a case of involving 2 concurrent cancers, malignant mesothelioma and malignant melanoma.An 86-year-old man, complaining of dyspnea, was referred to our hospital for further examination of right pleural effusion and a lentigo on the 5th toe. The lentigo was excised and microscopic examination revealed malignant melanoma. Malignant mesothelioma was also suspected due to findings of a chest CT scan and elevated hyarulonic acid in the pleural effusion.Malignant mesothelioma was diagnosed thoracoscopic biopsy.This technique considered useful for early and definitive diagnosis of malignant mesothelioma.We also analyzed the patient's CDKN2 genotype by multiplex polymerase chain reaction, using primers of CDKN2 and β-globin.Despite chemotherapy, the patient died of respiratory failure after three months.The postmortem specimen of the mesothelioma showed deletion of the CDKN2 gene.This abnormality of the CDKN2 gene was not found in specimens from the malignant melanoma. Although we could not fully exclude the possibility of a technical failure in extraction of the DNA, we suggest that the CDKN2 gene might have been related to the oncogenesis of both cancer in this patient.
特定非営利活動法人日本肺癌学会の論文