Analysis of Urinary Fibronectin (UFN) using Human Lung Cancer Cells Transplanted into Nude Mice.
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概要
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Fibronectin is widely distributed in the body, i.e. in plasma, on basement membrane and so on. Since great amounts of urinary fibronectin (UFN) are seen in patients with cancer, UFN is considered to be related with cancer growth and metastasis. In this study, we transplanted human lung cancer cells (PC-9, PC-14) into athymic nude mice subcutaneously, and measured both the concentration of UFN and tumor size of the mice periodically. We also analyzed the changes of UFN in relation to the growth of the tumor. As a result, the levels of UFN increased after cancer cell transplantation, and a correlation between tumor growth and UFN levels was observed statistically. Histopathologically, these subcutaneous tumors consisted of cancer cells, and they were positive for immunohistochemical staining with the ABC method using anti-fibronectin monoclonal anti-body. No metastatic lesions were seen in the mice. We conclude that urinary fibronectin is derived from cancer cells and increases with the growth of the tumor.
- 特定非営利活動法人 日本肺癌学会の論文
特定非営利活動法人 日本肺癌学会 | 論文
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