A Case of Oncocytic Carcinoid of the Lung.

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A 54-year-old man was admitted complaining of bloody sputum. A chest-roentgenogram showed atelectasis of the right middle and lower lobes. The level of urinary 5-HIAA was elevated but carcinoid syndrome was not observed. Bronchoscopy revealed a dark reddish polypoid tumor occluding the truncus intermedius. Right middle and lower sleeve bilobectomy was performed. No metastasis to the lymph nodes was observed. The level of urinary 5-HIAA had normalized after the surgery. Light microscopic findings revealed large cells with abundant granular eosinophilic cytoplasm. Grimelius stain revealed numerous argyrophilic granules in the cytoplasm. However, Fontana-Masson stain for argentaffin granules and immunohistochemical stain for serotonin were negative. Ultrastructural analysis revealed numerous mitochondria and dense neurosecretory granules in the cytoplasm. 25 months after surgery the patient has not shown recurrence or metastasis.
特定非営利活動法人日本肺癌学会の論文