The Relationship between Histocytological Features of Superficial Layer of Tumor and the Tumor Extent of Early Squamous Cell Carcinoma of the Bronchus.

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The relationship between histological features of superficial layers of the tumor and the degree of tumor extent of early squamous cell lung cancer was examined. In 33 lesions, the degree of keratinization was divided into the following 3 types; 1) well keratinized, keratinizing cancer cell composing 4 or more superficial layers of the tumor, 2) moderately keratinized, keratinizing cells composing only 1-3 superficial layers, 3) poorly keratinized, no or only a few keratinizing cells in the tumor tissue. Eight lesions well or moderately keratinized were covered with keratinizing cells with small pyknotic nuclei, of which the nuclear atypism were rather mild. These lesions tended to be misdiagnosed as benign atypia by sputum cytology. Of 18 well keratinized lesions, 14 were central type and 7 invaded beyond the cartilaginous layer. In 7 lesions with poor keratinization, 5 were superficial infiltrating type in growth pattern and 4 were more than 20mm in longitudinal length. These results indicate that the well keratinized type is likely to be centrally located and invade to a deep layer of the bronchus, and the poorly keratinized type is likely to extend superficially and widely in the bronchial wall.
特定非営利活動法人日本肺癌学会の論文