Flow Cytometric DNA Analysis in Small Lesions of Non-small Cell Lung Cancer.

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To assess the characteristics of small (≤8cm<SUP>3</SUP>) non-small cell lung cancer, DNA ploidy was investigated by means of flow cytometry using paraffin-embedded specimens from 62 patients. Of the 62 cases, 24 (39%) showed DNA aneuploidy and 38 had DNA diploidy. DNA ploidy was not associated with pathological stage, nodal status, pleural invasion, pulmonary metastasis, lymphatic invasion, vascular invasion, histological type, or grade of differentiation. The 5-year-survival rate was 67% in cases of DNA diploidy and 40% in those of DNA aneuploidy, but the difference was not significant. In 37 stage I cases and in 48 cases resected curatively, there were no statistical significant differences in the 5-year-survival according to DNA ploidy. But in 23 cases resected curatively in which no lymphatic or vascular invasion was proved microscopically, cases of DNA aneuploidy had a significantly lower 5-year-survival rate (44%) than cases of DNA diploidy (93%) (p<0.05). These results suggest that DNA ploidy is an independent prognostic factor and that DNA aneuploidy possesses occult malignancy.
特定非営利活動法人日本肺癌学会の論文