Evaluation of Response to Treatment of Small Cell Lung Cancer using Thoracic Computed Tomography.

概要

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Computed Tomography (CT) of the chest was performed as part of the initial and subsequent staging evaluations in 21 patients with small cell lung cancer who achieved a complete response on plain X-ray film after intensive chemotherapy, with or without thoracic irradiation. Patients consisted of 16 males and 5 females with a median age of 61 (range 37-75) years. Initial clinical staging revealed limited disease in 14 patients and extensive disease in 7.<BR>In all patients, CT demonstrated findings not observed on plain X-ray film after treatment. At the time of reevaluation with CT after treatment, there were four patterns: 3 (14%) cases of complete disappearance of abnormal lesion; 5 (24%) cases of partial lung collapse; 10 (48%) cases of small nodular lesion; and 3 (14%) cases of bronchial wall and pericardial thickening. The latter two patterns were associated with more frequent relapse in the chest (9/13) when compared with the other two patterns (2/8).<BR>Our study demonstrated that CT may contribute to more accurate restaging after treatment in small cell lung cancer patients and may reveal earlier recurrence in the chest.
特定非営利活動法人日本肺癌学会の論文