The Clinical Significance of Histologic Subtyping in Small Cell Lung Cancer in Terms of Chemotherapeutic Effect and Prognosis.:in Terms of Chemotherapeutic Effect and Prognosis

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• Several recent reports have suggested that the significance of defining "small/large cell carcinoma" or "undifferentiated carcinoma, small cell type (UCS)" as a new histologic subtype of small cell lung cancer (SCLC). This proposal has been based entirely upon a clinical tendency of UCS to be more resistant to chemotherapy than other subtypes of SCLC. Histological examination of UCS showed that relatively small and polygonal cells were in the majority. They also had clear or vesicular nuclei and prominent nucleoli with distinct celluar borders. Small numbers of intermediate or large cells could also be found. Thirty six patients treated with platinum compounds and etoposide were entered in this study in order to evaluate the clinical significance of UCS in the histopathologic subclassification of SCLC. Oat cell type was diagnosed in 13 patients (36%), intermediate subtype was diagnosed in 18 patients (50%) and UCS in 5 patients (14%). Among 5 UCS cases, complete response (CR) was obtained in 1 and partial response (PR) in 4. Survival periods for the UCS cases were 7, 13, 19, 32 and 61+ months, respectively. There were no significant differences in response to chemotherapy and survival period between the UCS patients and other SCLC patients. Our observations were in sharp contrast to findings of previous reports which attempted to define UCS as a distinct clinical entity because of the poor response to chemotherapy as well as the dismal prognosis.<BR>This discordance might be explained by the difference in the chemotherapeutic regimens employed. Thus, in consideration of advances in chemotherapeutic agents, UCS patients should be treated with similar protocols and philosophy as in the case of other SCLC patients.

• 特定非営利活動法人 日本肺癌学会の論文

特定非営利活動法人 日本肺癌学会 | 論文

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