Immunohistochemical Approach to Evaluation of the Growth Potential of Lung Cancers Using Monoclonal Antibody Ki-67.
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概要
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By immunohistochemical staining with monoclonal antibody Ki-67, growth potential was investigated in 79 resected lung cancers. The percentage of Ki-67 positive cells was defined as growth fraction: GF (%). The GF of squamous cell carcinoma (21.64±8.17%) was significantly higher than that of adenocarcinoma (11.86±9.60%). The GF of small cell carcinoma was high (38.31%). In squamous cell carcinoma, there was no correlation between the GF and other pathological prognostic factors. However, in adenocarcinoma, comparison of the GF with pathological stage, tumor size, lymph node metastasis, pleural invasion, vascular invasion, histological differentiation and survival rate showed a significant correlation between the GF and each of these factors. Thus, it was suggested that the Ki-67 GF is a useful new prognostic factor of adenocarcinomas of the lung.
- 特定非営利活動法人 日本肺癌学会の論文
特定非営利活動法人 日本肺癌学会 | 論文
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