An attempt to determine the origin of cancer by a histopathological study of squamous cell carcinoma of the bronchus less than 1mm in size.
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概要
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The purpose of this study was to investigate the histogenesis of squamous cell carcinoma of the bronchus. 108 resected specimens of roentgenographically occult lung cancer (ROLC) detected between April 1982 and May 1989 were examined histologically using the method of serial block sectioning at thicknesses of 2 mm. All the initial slides obtained from each block were reviewed. There were 4 carcinomas which involved only one block and were less than 1 mm in section. Some of the initial slides revealed squamous metaplasia with marked atypia or a nest of atypical cells which was suggestive of the presence of carcinoma in the block. These suggestive blocks were serially sectioned entirely. There were 7 tiny carcinomas enclosed within the serial sections. The total of 11 lesions were investigated by careful histological examination concerning the cellular features of the tumor and the morphological changes of the epithelium contiguous to it. Two lesions were situated within a focus of squamous metaplasia with marked atypia and 2 lesions bordered on it. Markedly atypical basal cells were arranged under the tumor and continuously on the basement membrane in 4 lesions. There was one lesion which bordered on the normal appearing epithelium and on basal cell hyperplasia. Two lesions were contiguous only to normal epithelium. There is no denying that squamous cell carcinoma may arise in the normal epithelium. But it was suggested that squamous metaplasia with marked atypia and a line of markedly atypical basal cells can also be the origin of cancer.
- 特定非営利活動法人 日本肺癌学会の論文
特定非営利活動法人 日本肺癌学会 | 論文
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