Cell-mediated immunity in primary lung cancer assessed with respect to lymphocyte subsets.

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Cell-mediated immunity (CMI) was studied in 55 patients with primary lung cancer before treatment. The response to in vivo tuberculin skin test and in vitro lymphocyte blastogenesis to PHA or Con A and changes in lymphocyte subsets were examined.<BR>In advanced lung cancer (stage N), decreases were observed in the response to tuberculin skin test (p<0.05), lymphocyte blastogenesis, the number of OKT4-cells (p<0.005) and the ratio of OKT4-cells to OKT8-cells (p<0.025), whereas the number of OKT8-cells was elavated (p<0.05). However, these results were not related to the cell types of lung cancer. Therefore, heavy smoking depressed OKT4-cells and the OKT4/OKT8 ratio (p<0.005) and elevated OKT8-cells (p<0.05).<BR>After chemotherapy in 8 patients and radiotherapy in 6 patients, OKT4-cells and the OKT4/OKT8 ratio were decreased but OKT8-cells and OKIal-lymphocytes were elevated. The percentage of each lymphocyte subset was not related to the duration of survival. Our data indicate that advanced stage of lung cancer have depressed CMI with and imbalance of T-cell subsets and that the study of lymphocyte subsets in patients with lung cancer is useful in monitoring immunity.
特定非営利活動法人日本肺癌学会の論文