A case of sarcoma originating from the left main pulmonary artery.

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A case of a 32-year-old man with primary sarcoma originating from the left main pulmonary artery was reported. The left hilar mass was found on chest roentgenogram. Pulmonary arteriography showed complete obstruction of the left main pulmonary artery and long segmental stenosis of the right main pulmonary artery.<BR>The open biopsy specimen was composed of pleomorphic tumor cells vaguely fascicular but generally disorganized. By electron microscopy, the tumor cell cytoplasm was shown to contain numerous microfilaments aligned longitudinally, associated with dense bodies, suggestive of myogenic sarcoma<BR>Regression of the tumor was obtained by radiation therapy followed by chemotherapy without improvement of the pulmonary arterial obstruction. The patient died of acute renal failure after high dose methotrexate chemotherapy. At autopsy, the tumor was confirmed to originate from the left main pulmonary artery and was almost completely composed of necrotic cells suggestive of the effect of treatment.
特定非営利活動法人日本肺癌学会の論文