Sequential changes of bronchial epithelial cells in heavy smokers. Fluorescence cytophotometric nuclear DNA analysis.:Fluorescence Cytophotometric Nuclear DNA Analysis

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We have sequentially observed histological and cytological alterations in bronchial epithelial cells of 9 heavy smokers. Nuclear DNA contents of bronchial epithelial cells in these cases were also measured by cytofluorometry.<BR>Eight of the cases were diagnosed as either basal cell hyperplasia, squamous cel l metaplasia or squamous cell metaplasia with mild atypia. One case was diagnosed as carcinoma in situ on the first biopsy. The 8 cases did not advance beyond squamous cell metaplasia to severe atypia or epidermoid carcinoma. The single case of carcinoma in situ did not return forsubsequent examinations for 44 months. The biopsy then showed invasive epidermoid carcinoma.<BR>DNA histograms of the bronchial epithelium were as follows: basal cell hyperplasia or squamous cell metaplasia, 2C mode and ranging from 2C to 4C; squamous cell metaplasia, with mild or moderate atypia, hyper 2C mode and ranging from 2C to 6C; carcinoma in situ, polyploid pattern and ranging from 4C to 10C; invasive epidermoid carcinoma, aneuploid pattern spreading over 10C.
特定非営利活動法人日本肺癌学会の論文