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A case of pulmonary carcinoma in a man aged 66 employed in chromate manufacturing for 40 years was reported. Roentgenographically, the tumor was located in left S<SUP>3</SUP> a. Left upper lobectomy was performed. Histologically the tumor was a moderately differentiated adenocarcinoma. In view of the reported predominance of squamous cell carcinoma in occupational lung cancer, it is of interest that the histological type of the lung cancer of this patient was adenocarcinoma. Using an atomic absorption spectrophotometer, the analysis of the chromium content in the resected regional lymph node and lung tissue showed a remarkable augmentation of chromium in the lymphnode and in the deep anthracotic region of the lung tissue, compared with that of similar anthracotic lung tissue from an elderly man without apparent exposure to chromate dust. Through X-ray microanalysis, a remarkable number of particles containing chromium were found in the anthracotic region of the lung. These findings suggest that long-term exposure to chromate dusts may lead to the occurrence of lung cancer.
特定非営利活動法人日本肺癌学会の論文