Tumor Doubling Time and PPD Skin Test Reactivity in Resected Cases of Lung Cancer Surviving over 5 years

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Variable clinical parameters were examined in 57 resected lung cancer cases surviving more than 5 years (5-year survival cases). PPD skin test reactivity (PPD) and tumor doubling time (tD) were studied and compared with those of 106 patients with resectable lung cancer (resected cases).<BR>In 5-year survival cases, a relatively younger age distribution and increased Hb concentration in peripheral blood were noted. The PPD showed greater reactivity in 5-year survival cases, especially in adenocarcinoma cases. 5-year survival cases showed a doubling time of 210 days while that of resected cases was 106 days (P<0.01); squamous cell carcinoma in the former cases showed a tD of 264 days and in the latter 94 days (P<0.01). In the patient group with greater PPD reactivity, the tumor diameter tended to be smaller on chest x-ray film with the longer tD.These observations indicate that tumor doubling time is an important parameter in the prognosis of lung cancer patients and that an immunologic mechanism is involved in the tumor growth rate, though it may be very weak.
特定非営利活動法人日本肺癌学会の論文