Monocyte Function in Patients with Bronchogenic Carcinoma
スポンサーリンク
概要
- 論文の詳細を見る
Function of peripheral blood monocyte in 59 untreated patients with bronchogenic carcinoma was studied and compared to that of normal controls. The total leukocyte count was determined with a Coulter counter, whereas the differential was determined on the basis of 500 cells counted. The absolute monocyte count was found by applying the percent of monocytes in the differential to the total leukocyte count. The mean absolute number of monocytes was 294±176/cmm in patients with bronchogenic carcinoma and 299±144/cmm in controls. However, there was no significant difference between these two groups. Furthermore monocyte number, clinical stage and histological type also failed to demonstrate any significant correlations among them.<BR>Lysosomal enzyme activity of monocyte was histochemically determined by ability of staining to beta-galactosidase. The mean percentage of positive monocytes was 23.1±12.1 in patients with bronchogenic carcinoma and 33.7±12.1 in controls, which showed significant difference between these two groups.<BR>Monocyte chemotactic response was measured in vitro by Boyden's millipore technique using zymosan activated human serum as chemoattractant. It was significantly reduced in bronchogenic carcinoma (19.4±7.0) to compare with that of controls (34.8±8.0). In addition, combination chemotherapy further reduced the monocyte chemotactic response rate.<BR>Ability of monocytes to phagocytose complement fixing zymosan was also significantly lowered in patients with bronchogenic carcinoma.<BR>These data suggested that neoplasm affect monocyte function which can possiblydestruct malignant cells immunologically.
- 特定非営利活動法人 日本肺癌学会の論文
特定非営利活動法人 日本肺癌学会 | 論文
- 診療科からみた新しいTNM病期分類（UICC-7）の問題点と課題?画像診断からみた問題点と課題?
- 新潟県における肺がんの解析
- 慢性血栓塞栓性肺高血圧症合併肺腺癌に対する左上葉切除術を施行した1例
- 肺がん検診における判定基準の改訂（2）：B，C，D判定に関して
- 片側性多発脳神経障害（Garcin症候群）を契機に発見され，化学療法により神経症状の改善を得た小細胞肺癌の1例