A Clinicopathological Study of Lymph Node Biopsy in Lung Cancer Autopsy Cases

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概要

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• Seventy-six cases, received lymph node biopsy, out of consecutive 409 lung cancer autopsy cases from 1958 to 1975 at the Department of Pathology, University of Tokyo, were studied clinicopathologically. Lymph node biopsy is losing its diagnostic value in lung cancer with the peak of 30% of 1964 to 1966, whereas bronchial fiberscope biopsy is gradually increasing since 1963 and now almost the same incidence, i. e. 18%, as lymph node biopsy. Difficulty in histological diagnosis and variety of lung cancer pattern at both biopsy and autopsy are discussed. The average clinical course after the confirmation of lung cancer by lymph node biopsy was 4.3 months for the entire cases, 6.8 months in squamous cell ca., 5.8 months in small cell anaplastic ca., and 2.7 months in adenoca. cases. There were 2 cases, alive more than 12 months after the biopsy, a case of small cell anaplastic ca. survived 29 months and a case of sq. cell ca. survived 42 months, both received successful radiotherapy.<BR>As for histological findings of lymph nodes and prognosis after the biopsy, preservation of lymph node structure and vascular permeation by cancer cells are not contributory in lymph node metastases of lung cancer more distant than the supraclavicular region. As indicators of immunological activity of patients, paracortical lymphoid hyperplasia, germinal center activity and sinus histiocytosis are all beneficial findings for better prognosis which is statistically significant.

• 特定非営利活動法人 日本肺癌学会の論文

特定非営利活動法人 日本肺癌学会 | 論文

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