A pathological study on the lung of rats given hexachlorotetrafluorobutane (HCTFB) and 4NQO

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• In order to estimate the useful method for the induction of the local pulmonary fibrosis and to analyse the relationship between the local pulmonary fibrosis and carcinogenesis, this experiment was performed 72 Wister rats were divided into the following 3 groups.<BR>Group C: 22 rats received the single intravenous injection of hexachlorotetrafluorobutane (HCTFB).<BR>Group A: 15 rats received the single intravenous injection of HCTFB, followed 67 days after by the subcutaneous injection of 4-nitroquinoline71-oxide (4 NQO). The subcutaneous injection of 4NQO was repeated weekly until the total dose of 4NQO reached 10 mg (20 times).<BR>Group B: 35 rats received the single injection of HCTFB intravenously. These rats were given the subcutaneous injection of 4NQO simultaneously once a week until the total dose of 4NQO reached 10 mg (20 times).<BR>All rats died or were killed were necropsied and examined histologically. The following results were obtained.<BR>The local pulmonary fibrosis accompanied with elastosis was induced at a high rate by the single intravenous injection of HCTFB. The fact that the local pulmonary fibrosis invariably occured by the intravenous injection of HCTFB indicates that it is an advantageous method for studying the experimental carcinogenesis of the scar cancer.<BR>Atypical epithelial hyperplasia was often observed around the site of the local pulmonary fibrosis, also there was one case of pulmonary cancer in the both group A and B respectively. There was obvious fibrosis accompanied with elastosis in the central portion of these two cases of pulmonary cancer.<BR>It seems to us that there is intimate relationship between the local pulmonary fibrosis and carcinogenesis.

• 特定非営利活動法人 日本肺癌学会の論文

特定非営利活動法人 日本肺癌学会 | 論文

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