A New Floating Cell Line (OAT) Derived from Human Pulmonary Cancer of Oat Cell Type
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概要
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A cell line was newly established from a lymph node with metastasis from oat cell carcinoma of the lung.The culture medium consisted of RPMI-1640 supplemented with 20% fetal bovine serum. The culture cells grewfloating free in the culture fluid and have been serially subcultured for 80 generations, up to date. Doubling timewas approximately 24 hours. Multi-lobulated nuclei and well-developed Golgi apparatus were prominent and secretorygranules were occasionally observed. No virus particles were found. Repeated examination ofimmunofluorescence revealed no evidence of immunoglobulin synthesis and EB virus production. Chromosomalanalysis of cultured cells of the 8th generation revealed the modal number of 47 chromosomes and the karyotypicanomaly of B5q+, t (Alq+; Cq-)- in all of the mitotic cells.<BR>These characteristics of this cell line obviously differ from the lymphoblastoid cell lines derived fromthe human lymphoid tissues, strongly supporting the possibility of its cancer cell origin. This cell line, hence, wasdesignated as OAT line after oat cell carcinoma.
- 特定非営利活動法人 日本肺癌学会の論文
特定非営利活動法人 日本肺癌学会 | 論文
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