p53 mutations in MeIQ-induced mouse forestomach tumors.
スポンサーリンク
概要
- 論文の詳細を見る
A method was established for detecting mutations in the mouse p53 gene by cDNA-PCR-SSCP, using four cell lines which were derived from forestomach tumors induced in CDF<SUP>1</SUP> mice by 2-amino-3, 4-dimethylimidazo [4, 5-f] quinoline (MeIQ). All the cell lines were demonstrated to have mutations in exons 4, 5, 7 and 10, respectively, and the method was confirmed to be efficient and reliable. It was therefore used to analyse the role of p53 gene mutations in forestomach carcinogenesis induced by MeIQ, by examining four original tumors, one papilloma, two primary carcinomas and one lymph node metastasis. The papilloma (F 14) and the carcinoma (F 12) had mutations, but the lymph node metastasis of F 12 mouse (F 12 LN) did not. These results thus indicate that p53 mutations may occur relatively early but do not confer any predisposition for lymph node metastasis. (J Nippon Med Sch 1977; 64: 39-44)
- 日本医科大学医学会の論文
日本医科大学医学会 | 論文
- わが国における腸チフスの疫学的考察--1973年〜1976年届出菌検出例を中心として
- 臨床および実験報告 二絨毛膜双胎妊娠における高年初産の検討
- 救急災害医学の確立と展望[含 略歴 研究業績] (定年退職教授記念講演会講演要旨)
- 臨床のために 関節リウマチの診断と治療
- TNFファミリーの制御による関節リウマチ治療の可能性 (特集 第15回公開「シンポジウム」(アレルギー・膠原病に対する新たな展開))