Glomerular change after the administration of anti-Type IV collagen sheep serum in mice regarding IgA mesangial deposition.:Regarding IgA mesangial deposition
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The nephritogenicity of the anti-Type IV collagen sheep serum was investigated by administering it intravenously to BALB/c, C3H and ddY strain male mice which had previously been treated with sheep IgG and FCA. The animals were sacrified chronologically at 3 days and 1 week up to 10 months. At each interval 2 to 4 mice were sacrified. A control group without any treatment was similarly studied.<BR>An immunofluorescent microscopic study revealed that the sheep IgG was specifically localized in the mesangial region. A similar distribution pattern of the mouse IgG and C3 was also confirmed. However, morphological features were seen to be preserved. At 3-4 months, accumulation of the mouse IgA was noted in the mesangial region. This feature is particularly prominent in the ddY mice strain. The amount of IgA deposition was well correlated with the immunochemical determinative amount of IgA in the serum and with the alteration of morphological features.<BR>However, serum IgA antibody activity against sheep IgG in vitro by ELISA showed no close interrelation with the amount of mesangial IgA deposition. Moreover, the renal eluated IgA from the ddY mice, which disclosed the IgA deposition in the mesangium, showed essentially no antibody activity to the sheep IgG. However, the antibody activity was well maintained in the eluted IgG.<BR>Based on these observations, it is justifiable to assume that the mouse IgA was non-immunologically trapped in the functionally disturbed mesangium by the locally formed IgG immune complex which is produced by the treatment of anti-Type IV collagen sheep serum to mice. This observation may be useful in clarifying the causative process of human IgA nephropathy.
- 日本医科大学医学会の論文
日本医科大学医学会 | 論文
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