Albuminuria in primary and junior high school pupils after running.
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概要
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Changes in the amount of urinal protein and β<SUB>2</SUB>-microglobulin (β<SUB>2</SUB>-MG) were observed after middle distance running in 46 primary school boys and 46 junior high school boys, aged from 6 to 14 years old.<BR>The running distance was varied according to their age, 800m for boys aged from 6 to 7-year-olds, 1, 200m for 8 to 9-year-olds, 1, 700m for 10 to 11-year-olds and 1, 500m for 12 to 14-year-olds.<BR>Urine was collected from each subject before and 30min after running, and its total urinal protein was analyzed by the Lowry method and β<SUB>2</SUB>-MG by the reverse passive hemaggulutination method.<BR>In the primary school boys at rest, total urinal protein was 16.8mg/dl and β<SUB>2</SUB>-MG 5.69μg/dl, while 39.3mg/dl and 133.22μg/dl, respectively, at 30min after running. In the junior high school boys at rest, they were 18.9mg/dl and 4.32μg/dl, respectively, and 78.3mg/dl and 662.98μg/dl, respectively, at 30min after running. Other urinal protein, which did not have its origin in blood plasma, was calculated before and 30min after running utilizing the results of Poortmans' research (1968), and no change was observed in the concentration before and after running. Therefore the increase in urinal protein after exercise would seem to have originated mainly from blood plasma.<BR>β<SUB>2</SUB>-MG increased not only its quantity in the urine (see above) but also its ratio in the urinal protein (7 to 80 times larger after running than before). There results indecate that permiability in the glomerulus and absorption in the proximal tubule changed as regards low molecular protein.<BR>By multiple regression analysis it was revealed that urinal protein at 30min after running was significantly correlated to weight, running time and concentration of urinal protein at rest of the subject. The contribution rate was from 60.02 to 74.59% in each aged group. It was found that there was a positive correlation between weight and concentration of urine protein at rest, but a negative correlation between running time and the concentration at 30min after running.
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