An ultrastructural study on the changes of the anterior lobe of the pituitary gland induced by severe thermal burns.
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The ultrastructural change in the anterior lobe of the pituitary gland of Wistar rats which were induced by severe thermal burns were investigated by electron microscope. The results obtained were as follows:<BR>1) Swelling of the cell mitochondria, showing a characteristic vesicular form as seen in endo-crine organs, was noted immediately after the severe thermal bums were inflicted and the swelling continued for 48 hours. In the later stages, recovery from the swelling was noted. However, renewed swelling was observed 3 weeks after infliction of the burns. The change was very visible after 6 weeks. The change in the mitochondria corresponded to vascular stasis of the capillary vessels and disintegration'in the endothelial cells.<BR>2) Six hours after the burns were inflicted abundant secretory granules were liberated form the cells of the anterior lobe and dispersed in the stroma of the perivascular spaces. Liberation of the ribosomes was also discernible in the stroma of the anterior lobe which suggests an intensive cellular injury induced by the shock of severe thermal burns.<BR>Based on these observations it has been suggested that an increase in pituitary hormones at the initial stage of the shock would be a cardinal pathological process.<BR>3) Liberation of secretory granules was confirmed, substantiating ultrastructural evidence of a hyperfunctional state of hormone secretion.<BR>A similar change persisted until 6 weeks after infliction of the severe thermal burns, suggesting that an identical hyperfunctional state might last until this stage.<BR>4) It was clear that the application of the Periodic Acid Methenamine Silver (PAM) Staining Procedure was very effective in evaluating the property of the cellular component of the endocrine system. Moreover, The PAM Staining Procedure was also effective in detecting the properties of the basement membrane as well as supporting connective tissue components.
- 日本医科大学医学会の論文
日本医科大学医学会 | 論文
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