Studies on placenta-originating enzymes (CAP, LAP, HSAP) in maternal serum and placenta tissue in normal pregnancy and gestosis.
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this comparative study was to examine to what extent maternal serum values of the three enzymes, cystine aminopeptidase (CAP), leucine aminopeptidase (LAP), heat-stable alkaline phosphatase (HSAP) reflected the enzymatic activity in the placental tissue. The maternal serum values of CAP, LAP, and HSAP were measured immediately before delivery and the activity of these three enzymes in the placental tissue was also measured in 85 normal pregnancies and in 25 cases of gestosis. Also the serum values of these three enzymes were measured in 232 pregnant women in order to see how useful they were for clinical diagnosis. The following results were obtained :<BR>1) The serum concentration of CAP showed higher values in the gestosis group than in the normal pregnancy group, but no significant difference was observed. The placental enzymatic activities (mu/mgp), (mu/wwg) and (U) showed higher values in the normal pregnancy group than in the gestosis group, but no significant difference was observed.<BR>2) The serum concentration of LAP was higher in the gestosis group than in the normal pregnancy group, but no significant difference was observed. The placental enzymatic activity (mu/mgp) was higher in the normal pregnancy group than in the gestosis group (p<0.05). The placental enzymatic activities (mu/wwg) and (U) were higher in the normal pregnancy group than in the gestosis group, but no significant difference was observed.<BR>3) The serum concentration of HSAP was higher in the normal pregnancy group than in the gestosis group, but no significant difference was observed. The placental enzymatic activities (mu/mgp), (mu/wwg) and (U) were lower in the normal pregnancy group than in the gestosis group, but no significant difference was observed.<BR>4) When we determined the correlation between the serum concentration of the three enzymes and the overall placental enzyme amount, it was found that for CAP (r=0.42, p<0.01), for LAP (r=0.27, p<0.05), and for HSAP (r=0.37, p<0.01). Thus all the correlation coefficients were quite low.<BR>5) When we determined the serum concentration and the overall placental amounts of the three enzymes, CAP, LAP and HSAP in the gestosis group, no correlation was obseved.<BR>6) In 232 pregnant women we analyzed the single measurement value and the repeated continual measurement pattern of the three enzymes in the serum and found that for all three enzymes we obtained better results from the analysis of the repeated continual measurement pattern of values than in the single measurement determination. Thus the latter was considered to be superior for purpose of diagnosis.
- 日本医科大学医学会の論文
日本医科大学医学会 | 論文
- わが国における腸チフスの疫学的考察--1973年〜1976年届出菌検出例を中心として
- 臨床および実験報告 二絨毛膜双胎妊娠における高年初産の検討
- 救急災害医学の確立と展望[含 略歴 研究業績] (定年退職教授記念講演会講演要旨)
- 臨床のために 関節リウマチの診断と治療
- TNFファミリーの制御による関節リウマチ治療の可能性 (特集 第15回公開「シンポジウム」(アレルギー・膠原病に対する新たな展開))