Diphtheria-antitoxin level and effect of the immunization with the toxoid in Chiang Mai in 1977-1982.
スポンサーリンク
概要
- 論文の詳細を見る
Seroepidemiology of diphtheria in Chiang Mai, North Thailand through 1977 to 1982 and development of the antitoxin in the blood of children immunized with the toxoid were studied. Antitoxin titers of 763 sera with unknown immunization history and of 1, 059 sera with known immunization history were determined by using the microneutralization-cell culture method.<BR>Among persons with unknown immunization history, the percentage of the antitoxinpositive in 10-14 years old subjects in 1979 was higher, as compared with the same age group in 1977, while that in 20 or more years old subjects in 1977 and 1980 were lower than in 1979. Percentage of the antitoxin-positive sera increased according to age. Geometric mean titer of the antitoxin-positive sera in 15-19 year-old subjects was higher in 1979 than in 1977, and higher also than in 5-9 year-old subjects in 1979.<BR>All of the children being immunized in accordance with strict regulations of the Comprehensive Child Care Clinic, Chiang Mai University had the positive antibody. In experiments with this group, a significant increase in the antitoxin titer was observed one month after the booster immunization, and a gradual decrease of the antitoxin titer was observed through 1 to 37-71 months after the last booster immunization in the group of 5-9 years old. Decline of the titer was not observed in the group of 10-17 years old through 16 100 months after the last booster immunization, and the geometric mean titers of this group were 0.580 or more IU/m<I>l</I>.<BR>In Wat Kau Khum school in the suburbs of Chiang Mai, one shot of the immunization produced the seroconversion in 88.2% of the children, and the geometric mean anti-toxin titer of the antibody-positive sera was 4.491 IU/m/ after the one shot.
- 日本医科大学医学会の論文
日本医科大学医学会 | 論文
- わが国における腸チフスの疫学的考察--1973年〜1976年届出菌検出例を中心として
- 臨床および実験報告 二絨毛膜双胎妊娠における高年初産の検討
- 救急災害医学の確立と展望[含 略歴 研究業績] (定年退職教授記念講演会講演要旨)
- 臨床のために 関節リウマチの診断と治療
- TNFファミリーの制御による関節リウマチ治療の可能性 (特集 第15回公開「シンポジウム」(アレルギー・膠原病に対する新たな展開))