Study of countermeasures to prevent Di(2-etylhexyl)phthalate elution from blood tubing
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A relationship between mechanical load and the elution of Di (2-etylehexyl) phthalate (DEHP) was observed with a primary focus on the blood circuit pump tubing site. Furthermore, this study investigated whether the pump tubing internal surface coating, change in the materials, and utilization of tubing with a plasticizer Tris (2-etylehexyl) trimellitate (TOTM) substituted for DEHP, would be effective in preventing DEHP elution.Methods: 1. An Experiment with Pump-Tubing. Pump tubing with 0.8cm internal diameter and 100cm length was filled with 5% albumin solution. 1) After the tubing was filled with the test solution, under the temperature of 8°C for 48 hours. The DEHP level was measured after the period of 48 hours. 2) The tubing was attached to a blood pump. And the test solution was circulated at a flow rate of 100mL/minute for 60 minutes. Before and after circulation DEHP levels were measured. Two types of blood tubing were examined in this experiment: A commercially available tubing and a tubing with conventional heparin coating on the internal surface. 2. An Experiment with an Entire Blood Tubing. 2-1) Tubing was filled test solution and the test solution was circulated at a flow rate of 100mL/minute for 240 minutes. Before and after circulation, DEHP levels were measured. 2-2) The test solution in the tubing was circulated for 60 minutes using tubing with different internal diameters. Before and after circulation DEHP levels were measured. Four types of tubing were examined in this experiment: A commercially available tubing using DEHP, a commercially available tubing with an alternated pump tubing with a different silicon material, an alternated circuit with TOTM on the pump tubing, and an all TOTM tubing system. The internal diameters of the tubing were 118mL and 136mL.Results: 1. The DEHP levels of these two types of tubing both increased after the neglect experiment and the mechanical load experiment. 2-1) With the commercially available tubing, the DEHP levels after circulation showed a greater increase than that before circulation. 2-2) There was no elution observed with TOTM tubing. The system with silicon material only on the pump tubing and the alternated TOTM tubing prevented DEHP elution fifty percent (50%) more than the commercial available tubing circuits.Conclusion: Fifty percent (50%) of DEHP elution in the entire tubing was derived from the pump tubing site; thus, 50% of DEHP elution can be prevented by changing the pump tubing material and its placement method. The DEHP and/or TOTM level was not detected in blood tubing with a TOTM plasticizer.
- 社団法人 日本透析医学会の論文
社団法人 日本透析医学会 | 論文
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