Effects of fiber length and filling rate on reduction rate of serum low molecular weight proteins: In vitro and clinical evaluation for a newly developed dialyzer housing

スポンサーリンク

概要

• 論文の詳細を見る

• A new polysulfone dialyzer (BS-1.6UL: BSL), characterized by a longer fiber length and an increased fiberfilling rate, has recently been developed by Toray Medical Co, Ltd (Tokyo, Japan). To determine the significance of the fiber length and the filling rate, the reduction rates of serum low molecular weight proteins were compared among BSL and two conventional dialyzers. The dialyzers tested were BSL, BS-1.6U (BSU, Toray) with a shorter fiber length compared to BSL, and PS-1.6UW (PSW, Kawasumi, Tokyo, Japan), a polysulfone dialyzer with a fiber length similar to that of BSL. In in vitro studies, discarded plasma from end stage renal disease (ESRD) patients and familial hypercholesterolemia patients were dialyzed in a recirculation batch system. The subjects of the clinical studies consisted of six ESRD patients. Both in vitro and clinical studies showed that the reduction rate of low molecular weight proteins was higher in BSL than in other dialyzers, whereas the reduction rate of small molecular substances were similar among the three dialyzers. Adsorption of small proteins and lipids did not significantly differ among the three dialyzers. Leukocyte and platelet counts, and the C3a levels of patients during dialysis did not significantly differ among the three dialyzers. Pressure drop was significantly higher in BSL (BSL>PSW>BSU) both in blood and dialysate compartments. Our results suggest that a longer fiber length and an increased fiber filling rate in dialyzer housing is efficient for the removal of low molecular weight proteins. The efficiency is presumably attributable to the inner filtration rate of the fiber accomplished by the high blood pressure drop in the blood and dialysate compartments.

• 社団法人 日本透析医学会の論文

社団法人 日本透析医学会 | 論文

• 4．血液浄化療法の生体適合性と腎性貧血
• PD-HD併用療法においての腎機能保護の可能性 : 第51回日本透析医学会ワークショップより
• 腹部大動脈人工血管の仮性動脈瘤破裂，および右大腿回旋動脈の仮性動脈瘤破裂をきたした血液透析患者の1例
• 5．透析患者のインスリン抵抗性と腎性貧血
• 摘出腫瘤の病理組織標本所見より頸椎腫瘍状石灰沈着症 (cervical tumoral calcinosis) と診断し得た維持透析患者の1例

もっと見る

スポンサーリンク