Five cases of septic shock hemoperfused with polymyxin B-immobilized fiber(PMX) whose level in T helper 1 lymphocytes(Th1) and T helper 2 cells(Th2) was monitored during the treatment.

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Th1 lymphocytes produce interferon (IFN)-γ and modulate cell-mediated immunity, while Th2 secrete interleukin (IL)-4 and modulate humoral immunity. Th1/Th2 balance in septic patients has recently been discussed. We report the assessment of whether PMX affects Th subsets in five patients with septic shock. The first case was a 57-year-old male with sepsis due to severe pneumonia and diabetic nephropathy. The second case was a 68-year-old male with sepsis secondary to pneumonia who had undergone regular hemodialysis due to chronic glomerulonephritis. Pathogenic bacteria of septic shock were pseudomonas aeruginosa in both cases. While, the third case was a 51-year-old male with postoperative sepsis who had received hemodialysis due to diabetic nephropathy, and the fourth case was a 76-year-old male with sepsis due to infectious gangrene of the inferior limb who had received hemodialysis due to nephrosclerosis. In both of these cases, pathogenic bacteria were methicillin resistant Staphylococcus aureus (MRSA). The fifth case was a 56-year-old male with sepsis due to abscess of iliopsoas musle who had diabetes mellitus, and the pathogenic bacteria were unkown. All five patients were treated with PMX, and we measured Th subsets before/after PMX administration. To assess the response to PMX in our patients, we divided them into two groups, the delayed response group (cases 1 and 2) and the prompt response group (cases 3, 4 and 5). The overall Th2 level predominance in Th1/Th2 balance before PMX was not noted. However, both Th1 and Th2 were higher before PMX and decreased after treatment in the delayed response group compared to levels in the prompt group.In conclusion, Th subsets didnot consistently change after PMX. However, Th1 and Th2 levels before treatment may be critically involved in the response to PMX in patients with septic shock.
社団法人日本透析医学会の論文

Five cases of septic shock hemoperfused with polymyxin B-immobilized fiber(PMX) whose level in T helper 1 lymphocytes(Th1) and T helper 2 cells(Th2) was monitored during the treatment.

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概要

社団法人日本透析医学会 | 論文

スポンサーリンク

Five cases of septic shock hemoperfused with polymyxin B-immobilized fiber(PMX) whose level in T helper 1 lymphocytes(Th1) and T helper 2 cells(Th2) was monitored during the treatment.

スポンサーリンク

概要

社団法人 日本透析医学会 | 論文

スポンサーリンク

社団法人日本透析医学会 | 論文