Clinicopathological study of bone tissues in hemodialysis patients with scondary hyperparathyroidism.
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The desferrioxamine (DFO) test and iliac bone biopsy were performed at the time of TPTX+AT. Amyloid (Am), aluminum (Al), and iron (Fe) deposits were studied in bone tissues by alkaline Congo red, Aluminon, and Berline blue staining, respectively. Various parameters of bone metabolism including serum levels of high sensitivity parathyroid hormone (HS-PTH), Bone Gla protein (OC), aluminum (Al), ferritin (Ft), and alkaline phosphatase (Alp) were determined simultaneously, and their relations with Am, Al, and Fe deposition were evaluated.Al deposits were observed in 5 of 11 patients, and the preoperative DFO test was negative in 1 of these. Fe deposition and Am deposition were seen in 2 patients each. No correlations were observed between Am, Al, or Fe deposition and serum β2-MG, Al, or Ft levels. The serum Alp level was within normal range in 8 of the 11 patients, but the serum OC level was significantly increased in all, suggesting the usefulness of this parameter in the diagnosis of secondary hyperparathyroidism.These results suggest that it is important to examine the deposition of Am, Al and Fe in bone tissues before TPTX+AT.
- 社団法人 日本透析医学会の論文
社団法人 日本透析医学会 | 論文
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