A study of the effect of hepatitis B vaccine and the function of immunity in patients undergoing chronic hemodialysis.
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The effect of hepatitis B (HB) vaccine and accompanying factors was investigated in maintenance hemodialysis patients.A study was conducted on 31 hemodialysis patients whose hepatitis B surface antigen (HBsAg), antibodies to HBsAg (anti-HBs) and antibodies to hepatitis B core antigen were negative. They were vaccinated 3 times (months 0, 1, 6) with 20μg HB vaccine and were divided into 3 groups according to anti-HBs levels (S/N;>10, 2-10, 2<). Phytohemagglutinin (PHA) skin test, subsets of peripheral blood lymphocytes, immunoglobulin levels, total protein (TP), hematocrit (Ht), c-parathyroid hormone (c-PTH) and age before HB vaccination were compared among groups.The percentage (81.8%) of anti-HBs positives in the normal group (>205mm) on the PHA skin test was much higher than that (35.0%) of the abnormal group (<20.5mm). The levels of the PHA skin test in the good responders to HB vaccine were significantly higher than those of weak responders and non responders. Furthermore, the levels of the PHA skin test in the good responders decreased suddenly after vaccination. There were significant differences between the good responders and the weak responders, and between the weak responders and the non responders, in subsets of peripheral blood lymphocytes and immunoglobulins, but no significant differences between the good responders and the non responders. No significant differences were seen in TP, Ht, c-PTH and age.These results suggest that the PHA skin test reflects the function of T-cells and is useful in predicting the effect of HB vaccination, and the quantity and frequency of vaccine should be increased for abnormal patients.
- 社団法人 日本透析医学会の論文
社団法人 日本透析医学会 | 論文
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