Clinical study of Lp(a) lipoprotein and coronary atherosclerosis in chronic hemodialysis patients.
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The relationship between degree of coronary occlusion, based on the results coronary arteriography, and lipids, particularly serum Lp (a) lipoprotein, was examined in chronic hemodialysis patients.Coronary arteriography was performed on 16 men undergoing chronic hemodialysis at our hospital who exhibited cardiac symptoms and ischemic changes on ECG. The degree of coronary occlusion was determined on the basis of the Gensini score and Lp (a) assay by ELISA.There was a statistically significant positive correlation between the Gensini score and Lp (a) level, with a correlation coefficient of r=0.50 (p<0.05). There was also a positive correlation between total cholesterol level and the Gensini score, with an r=0.59 (p<0.05). No correlation, however, was found between the Gensini score and triglycerides, HDL-cholesterol, VLDL, LDL, Apo A1, A2, B, C2, C3, E, atherogenic index, mean blood pressure, Brinkmann index, or Broca index.The coronary artery occlusion score was positively correlated with serum Lp (a) and total cholesterol levels, and the correlations were statistically significant, however, no correlations with other lipids, apoproteins or coronary risk factors were detected. Lp (a)should be considered a coronary risk factor in maintenance hemodialysis patients with chronic renal failure.
- 社団法人 日本透析医学会の論文
社団法人 日本透析医学会 | 論文
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