The cause of enfanced fibrinolytic activity during hemodialysis; The effect of heparin.:The effect of heparin

概要

論文の詳細を見る
In order to clarify the cause of enhanced fibrinolytic activity during hemodialysis (HD), the fibrinolytic activity was evaluated in 15 patients undergoing regular dialysis treatment (RDT) using new parameters including α2-plasmin inhibitorplsmin complex (α2PIC), tissue plasminogen activator (t-PA) antigen, plasminogen activator inhibitor-1 (PAI-1) antigen and von Willebrand factor (vWF) antigen, which is regarded as reflecting a release reaction to certain stimuli by the vascular endothelial cells. Furthermore, controlled cross-over investigations were performed to rule out the effect of heparin administration. During a single HD session, α2PIC exhibited a continuous, significant increase. The t-PA antigen significantly increased during HD, and the PAI-1 antigen significantly decreased during HD. The vWF antigen also significantly increased during HD. But heparin administration alone did not induce any significant increase in the α2PIC or t-PA antigen of RDT patients. An increase in the release of t-PA with the consumption of PAI-1 is likely to be a leading cause of enhanced fibrinolytic activity during HD. Our observations demonstrated negative results regarding the effect of heparin administration on enhanced fibrinolytic activity during HD.
社団法人日本透析医学会の論文