Pharmacokinetics of cefotaxime under hemofiltration with two different filters
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We investigated the pharmacokinetics of cefotaxime and desacetylcefotaxime in patients with renal failure who were undergoing hemofiltration and in a in vitro model of hemofiltration. The filters employed for hemofiltration were the PAN-50P filter and BK-1.0 filter. The conditions for hemofiltration were a blood flow rate of 100ml/min and a fluid replacement value of 1, 200ml/hr in vivo or 180ml/hr in vitro. The concentrations of cefotaxime and desacetylcefotaxime in serum and filtrate were determined by the HPLC method.In the in vitro model of hemofiltration, the half-lives of cefotaxime were 1.78hr on hemofiltration using the PAN-50P filter and 1.53hr on hemofiltration using the BK-1.0 filter. The transfer rates omission hemofiltration using the PAN-50P and 90.9% on hemofiltration using the BK-1.0 filter. In the case of fluid replacement at 1, 200ml/hr in hemofiltration using the PAN-50P filter, the serum cefotaxime concentrations at 5 min and 5hr after cefotaxime administration were 145μg/ml and 14.4μg/ml, and the half-life was 1.80hr. The mean serum concentration of desacetylcefotaxime reached 12.8μg/ml at 4hr. In the case of fluid replacement at 1, 200ml/hr in hemofiltration using the BK-1.0 filter, the serum cefotaxime concentrations at 5 min and 5hr after cefotaxime administration were 150μg/ml and 6.0μg/ml, and the half-life was 1.26hr. The mean serum concentration of desacetylcefotaxime reached 14.7μg/ml at 4hr. It was concluded that part of the cefotaxime was bound to the protein filtered on hemofiltmation using the BK-1.0 filter, and desacetylcefotaxime was bound to the large molecular protein which was not filtered on hemofiltration using the BK-1.0 filter.
- 社団法人 日本透析医学会の論文
社団法人 日本透析医学会 | 論文
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