Studies of factors limiting maximal aerobic work capacity in patients on chronic hemodialysis
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The purpose of the present study was to investigate the limiting factors of maximal aerobic work capacity in patients on chronic hemodialysis. Thirty-five stable chronic hemodialysis patients (HD patients) and fifty-two normal controls were used as subjects. HD patients were not complicated by valvular heart disease or coronary heart disease, and none had been given digitalis or β-blocker agents. Abnormal electrocardiograph results and blood pressure responses were excluded because of exercise stress in HD patients. In all subjects, functional aerobic impairment (FAI), left ventricular impairment (LVI) and peripheral circulatory impairment (PCI) were calculated using Bruce's formula. Hemoglobin concentration was determined before exercise stress test in HD patients. The results obtained were as follows.FAI, LVI and PCI in HD patients were significantly higher than those of normal control subjects. PCI was higher than LVI in HD patients. FAI was significantly correlated with both LVI and PCI in normal control subjects, whereas FAI was significantly correlated with only PCI in HD patients. Additionally, FAI was not significantly correlated with hemoglobin concentration in HD patients.In conclusion, the present observations suggest that the limit of maximal aerobic work capacity depends upon peripheral circulatory impairment with the exception of lower hemoglobin concentration level in chronic stable hemodialysis patients.
- 社団法人 日本透析医学会の論文
社団法人 日本透析医学会 | 論文
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