Plasma osteocalcin in hemodialysis patients

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Plasma concentrations of osteocalcin (BGP), other chemical factors of bone metabolism, and microden-sitometric parameters were measured in 26 patients on maintenance hemodialysis. In patients with 1α(OH)D3, the plasma BGP was 56.0±48.1ng/ml (mean±SD). In patients without 1α(OH)D3 it was 39.1±24.9ng/ml. High levels of plasma BGP appeared in most patients, but no significant difference was found between the 2 groups. Serum ALP, ACP and plasma c-PTH showed significant positive correlations between plasma BGP: respectively r=0.678, p<0.001, r=0.720, p<0.001 and r=0.737, p<0.001. Significant negative correlations were found between ΔGSmin, ΔGSmax, ∑GS/D and plasma BGP: respectively r=-0.424, p<0.005, r=-0.459, p<0.05 and r=-0.467, p<0.05. There were higher correlations between these factors in the high ALP group (>80iu) than in the normal ALP group (≤80iu). On the other hand, there were no significant correlations between serum Ca, P, calcitonin values and plasma BGP. During treatment of renal osteodystrophy, plasma BGP tended to be elevated in patients jointly administered elcatonin with 1α(OH)D3, which coorresponded to the change in plasma c-PTH.The measurement of plasma BGP is useful as one of the indicators of bone turnover in hemodialysis patients.
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