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We report a case of human immunodeficiency virus (HIV) infection with chronic anemia and persistent parvovirus B19 infection.Case: A 40-year-old man, a practicing homosexual, was admitted to our hospital, because of anemia, cough and dyspnea. Since two months before the adimission, severe anemia had continued. Bone marrow specimen showed erythroid hypoplasia. The cause of anemia was unknown. On the other hand, his HIV antibody was positive. Viral load in the plasma was 9.0×104 copies/ml and CD4 count was 70/μl. He suffered from Pneumocystis carinii pneumonitis and cytomegarovirus pneumonia, and was administered ST and antibiot ics. Soon after administration of the antibiotics, his peripheral blood showed severe panc ytopenia, probably due to drugs. G-CSF, predonisolone and highly active antiretrovirus therapy (HAART, d4T+3TC+IDV+RTV) were started. He immediately recovered from le ukopenia, thrombocytopenia and pulmonary infection, but mild anemia still continued. Parv ovirus B19 DNA was persisitently positive in his bone marrow.Discussion: Parvovirus infection in bone marrow might cause chronic anemia in a patient with acquired immunodeficiency syndrome.
日本エイズ学会の論文