Role of neutrophil migration on increased pulmonary microvascular permeability.
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概要
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The precise role of neutrophils in adult respiratory distress syndrome is not yet clear. Endotoxin administration is known to induce the permeability pulmonary edema with neutrophil migration into alveolar spaces. Leukotriene B<SUB>4</SUB> is known as a strong chemotactic factor. To clearify the roles of neutrophils on pulmonary microvascular injury, we compared the effects of endotoxin and leukotriene B<SUB>4</SUB> on lung lymph dynamics and neutrophil migration. Endotoxin caused increase in microvascular permeability and migration of neutrophils into alveolar spaces.<BR>Whereas leukotriene B<SUB>4</SUB> did not affect lung microvascular permeability. Neutrophils in broncho-alveolar lavage fluid after leukotriene B<SUB>4</SUB> administration increased to the same value as which after endotoxin administration. These results suggest that the neutrophil migration into alveolar spaces is not essential to develop the permeability pulmonary edema.
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