A murine model of pulmonary eosinophilia.
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概要
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The transnasal administration of the extract of a parasite <I>Ascaris suum</I> (Asc) to mice for 3 weeks produced marked eosinophilia in the broncho-alveolar lavage (BAL) fluid. Among several strains of mice, C57BL/6 developed the most eosinophils in the BAL. C57BL/6-nu/nu mice failed to develop the pulmonary eosinophilia.<BR>The oral administration of cyclosporin 50 mg/kg body weight every other day significantly suppressed the accumulation of eosinophils in the lung. These data indicate that the pulmonary eosinophilia caused by Asc is dependent on T lymphocytes. The mast cell deficient (WB×C57BL/6) F<SUB>1</SUB>-W/W<SUP>v</SUP> mice developed marked eosinophilia in the BAL, which shows that mast cells are not necessary in the formation of eosinophils in this model.
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