Urinary trypsin inhibitor and its clinical usefulness for diagnosis of acute phase reactant and renal disease.

概要

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Urinary trypsin inhibitor (UTI) is glycoprotein which is excreted in urine small amount in healthy subjects. Faarvang reviewed in 1965 that excretion of UTI in urine increased during various disease states, such as, bacterial infection, malignant neoplasma with metastasis, myocardial infarction, surgical operation, normal pregnancy, acute pancreatitis, and renal diseases.<BR>Thereafter, studies were carried out to investigate the apparent polymorphism of UTI, and to determine and characterize the amino acid sequence and cDNA structure of UTI. In addition to trypsin-inhibitory activity, UTI has been elucidated to have many biological activities including; inhibition of proteinases other than trypsin, stabilization of shock, improvement of acute pancreatitis, and endothelial cell growth factor. In recent works, however, UTI seems seldom to be cited in relation to an acute phase reactant.<BR>We were able to carry out the automated measurement of UTI which was suggested to be useful for clinical diagnosis of acute phase of various conditions and renal diseases.
日本炎症・再生医学会の論文