Analysis of arachidonic acid metabolites in the BALF of patients with bronchial asthma.
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Contributions of prostaglandin (PG) s, thromboxane (TX) s, and leukotriene (LT) s in the pathophysiology of bronchial asthma have not been clarified yet. In the experimental model of bronchial asthma, SRS-A and histamine are known to play an important role. But clinical analysis is rare. In this investigation we performed broncho-alveolar lavage (BAL) in bronchial asthma patients and measured chemical mediators in three fractions of BAL fluid (BALF) and peripheral venous blood.<BR>TXB<SUB>2</SUB> and 11-dehydro-TXB<SUB>2</SUB> were significantly increased in the BALF of patients with bronchial asthma. But their concentrations in the peripheral venous blood are not so high compared with those of control groups. PGD<SUB>2</SUB> and PGF<SUB>2α</SUB> were not detected in the peripheral venous blood, but their levels in BALF were elevated in BALF of patient with bronchial asthma. Levels of leukotriene C<SUB>4</SUB> were not elevated in BALF and peripheral venous blood compared with those of control group, but further study would be needed to evaluate the role of leukotrienes including LTC<SUB>4</SUB> and LTD<SUB>4</SUB>.
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