Prostaglandin E2 binding sites in the normal and nephrotic kidney in rats.
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概要
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The distribution and characteristics of renal prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) binding sites were examined in the normal and aminonucleoside-induced nephrotic rats by Scatchard analysis.<BR>PGE<SUB>2</SUB> binding site density in the medulla of normal rats was 2.7-fold higher than that in the cortex, but there was no significant difference in the dissociation constants (Kd) between cortex and medulla.<BR>The Kd in the kidney medulla of the nephrotic rats were significantly higher (P<0.05) than that of normal rats, while the densities remained without changes.<BR>These results indicate that PGE<SUB>2</SUB> binding sites of the normal rat kidney are distributed in the medulla more than in the cortex, and the affinities of PGE<SUB>2</SUB> binding sites in the nephrotic rat kidney are lower than those in normal rat kidney.
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