A relationship between superoxide dismutase and alcoholic liver injury.

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The serum SOD values were measured by using enzyme-linked immunosorbent assay and immunohistological investigation of SOD was evaluated in alcoholic liver injury (ALI) .<BR>Serum Cu, Zn-SOD and Mn-SOD exhibited an inclination to increase as the releasing enzymes, revealing especially high values for ALI. Mn-SOD proved more useful for clinical diagnosis of liver disease than Cu, Zn-SOD due to its significantly higher values.<BR>The localization modes of hepatic SOD were mainly the liver cytoplasm diffusion type in ALI. Immunohistological frequency of Cu, Zn-and Mn-SOD localization modes were as follows: Corresponding values of Cu, Zn-SOD and Mn-SOD were 63.2% and 52.7% in cytoplasm diffusion type, 42% and 0% in nuclear diffusion type, 42.1% and 0% in vacuolated membrane type, 15.8% and 0% in small granulosum type respectively.<BR>A close relationship was observed between ALI and immunohistological frequency of SOD in these studies, a particular protective physiological role of SOD against activated oxygen was strongly postulated.
日本炎症・再生医学会の論文