Stimulated production of active oxygen with anti-microsome antibody positive sera in Basedow's disease.
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概要
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To evaluate pathophysiological significance of anti-microsome antibody positive sera in Basedow's disease, we have examined the production of opsonized zymosan stimulated active oxygens in neutrophils and the chemotaxis stimulated by f-methyonylleucyl-phenylalanine. O<SUP>-</SUP><SUB>2</SUB> significantly increased with sera of Basedow's disease as compared with those of healthy subjects. However OH<SUP>⋅</SUP> production and chemotaxis have not significantly changed.<BR>Productive-stimulating factors are, therefore, suggested to be present in the sera of Basedow's disease. The association of the factors with hyperthyroidism was discussed.
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