Vasoconstrictory action of leukotriene D4 (LTD4) on the denuded coronary arteries in mongrel dogs.
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概要
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To clarify the vasoconstrictory action of leukotriene D<SUB>4</SUB> (LTD<SUB>4</SUB>) on the injured coronary arteries, 8 mongrel dogs were denuded by basket balloon catheter (denuded group) and LTD<SUB>4</SUB> (0.33μg) was directly administered into left anterior descending coronary artery. Hemodynamic parameters as well as epicardial ECG were recorded after LTD<SUB>4</SUB> administration. Another 8 non-denuded dogs were served as control.<BR>Furthermore, the influence of denudation to LTD<SUB>4</SUB>-induced coronary spasm was determined by coronary arteriography (CAG) . In results, a significant reduction of coronary blood flow (from 1.03±0.13 to 0.49±0.05 m<I>l</I>/kg/min. P<0.01) and a significant increase of coronary vascular resistance (from 6.5±1.0 to 12.7±2.5 mmHg/m<I>l</I>/min. P<0.01) concomitant with a marked prolongation of ST segment elevation on epicardial EGG (duration time 439±86 sec) were observed in denuded group as compared with non-denuded group. And, the exaggeration of LTD<SUB>4</SUB>-induced coronary spasm at the site of denudation was documented by GAG.<BR>These results suggested that the vasoconstrictory action of LTD<SUB>4</SUB> was exaggerated on the injured coronary arteries and which might play an important role of pathogenesis and deteriolation of myocardial ischemia.
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