Anti-inflammatory and analgesic action of indomethacin cream ointment containing drugs for stimulation of indomethacin absorption.

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We prepared 9 types of indomethcin gel and cream ointments cotaining lecithin (ELT), benzyl nicotinate (NB), collagen or β-cyclodextrin as a stimulant of the absorption of indomethacin. Analgesic and anti-inflammatory effects of these ointments were studied comparing with Inteban (Sumitomo, Co. Ltd.) after topical application of the skin. Inhibitory effect of AN-15 containing 1% indomethacin, 2% ELT and 0.1% NB was the best among the others and equal to Inteban on carrageenin-induced potentiation of vascular permeability and ultraviolet ray-induced erythema in the guinea pig skin. On ultraviolet ray-induced erythema, when a term of ultraviolet ray exposure was prolonged, AN-15 was more potent than Inteban, and AN-2 containing half the indomethacin concentration of AN-15 had a equal effect of AN-15 and Intedan. Inhibitory effect of AN-15 and AN-2 were equal to Inteban on adjuvant arthritis in rats. AN-15, AN-2 and Inteban inhibited hyperalgesia significantly in adjuvant arthritic rats. From these facts, it is concluded that AN-15 is equal to or more potent than Inteban in anti-inflammatory and analgesic action, and the addition of NB and ELT for stimulation of indomethacin absorption is effective.
日本炎症・再生医学会の論文