Effect of plasma fibronectin (P-FN) on neutrophil function. (2). Effect on chemiluminescence (CL) response and superoxide (O2-) production.:—<I> (2), Effect on chemiluminescence (CL) response and superoxide (O<SUP>-</SUP><SUB>2</SUB>) production</I>—
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This recent study examined the effect of P-FN on CL response and O<SUP>-</SUP><SUB>2</SUB> production induced by stimulation of neutrophil mem-brane with zymosan, n-formyl-methionyl-leucyl-phenylalanine, phorbol myristate acetate, Ca<SUP>2+</SUP> ionophore A 23187 and cytochalasin E. The relative intensity of luminol-dependent CL (LDCL) response was evaluated by ATP photometry, and O<SUP>-</SUP><SUB>2</SUB> production was spectrophotometrically measured by ferricytochrome C reduction in reaction mixtures with and without P-FN.<BR>The results showed that both LDCL response and O<SUP>-</SUP><SUB>2</SUB> production of neutrophil were enhanced by the presence of P-FN in a dose-dependent manner. But P-FN alone could not induce LDCL response and O<SUP>-</SUP><SUB>2</SUB> production. From these results, it is suggested that P-FN may supplement respiratory burst of neutrophil.
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