Experimental immune complex glomerulonephritis and platelet aggregability in whole blood.

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Serum sickness nephritis was induced by repeated i.v. injections of rabbit serum albumin into rat. Blood was drawn from abdominal artery and renal vein. In whole blood, platelet aggregability was determined at 2, 6, 8 and 12 weeks after the preimmunization. Nephritic rats were treatment with oral dipyridamole, 100 and 400mg/kg, for 3 days, and then the platelet aggregability was determined. At the beginning of experiment, normal rats showed 9.9 ohms in arterial blood and 9.2 ohms in renal blood as platelet aggregability, respectively. At the 2nd week, the rats challenged with the first antigen had the increased platelet aggregability in arterial blood and decreased one in renal blood. Then, platelet aggregability in both blood gradually augumented with day. In the 12th week, proteinuric rats showed 14.2 ohms in arterial blood and 9.6 ohms in renal blood. Dipyridamole, 400mg/kg, inhibited platelet aggregability by about 50% as compared with the control in both blood.
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