Experimental emphysematous bullae induced by carrageenan and Sephadex beads - The process of the disease.:—<I>the process of the disease</I>

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To elucidate the effects of disturbances of the pulmonary circulation on the formation of pulmonary emphysematous bullae, we studied changes in the parenchyma of the lungs insulted by both pulmonary embolization with Sephadex beads and carrageenan-induced pneumonia in rabbits. The treated lobes of the lungs showed severe carrageenan pneumonia and pulmonary embolism in earlier stages (at one or two week), large to small emphysematous bullae, at 1, 2, or 3 month, and small ones and severe irregular emphysema at 4 month. More animals had bullous lesions in the groups given the larger doses of Sephadex and killed at 2 months while a few in the groups given the smaller or none of Sephadex had them. Rabbits given larger doses of Sephadex and killed at 2 months had also giant bullous lesions or multiple bullous lesions, while few animals given smaller doses of it had giant or multiple lesions.<BR>These results suggest that the size and number of bullous lesions forming in the treated lobes depends to a certain degree on the dose of Sephadex. Giant and small bullous lesions are varieties of the same disorder, and disturbances of the pulmonary circulation are associated with the formation of bullous lesions.
日本炎症・再生医学会の論文