Effects of methyl-B12 on the inflammation induced by CdCl2 in the testis of rats.
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概要
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Effects of methyl-B<SUB>12</SUB> on the inflammation induced by CdCl<SUB>2</SUB> in the testis of rats, in which a remarkable increase of oxidative reaction was observed, were investigated. The results are summarized as follows: 1) Serum enzyme activities, i.e., Al-p, LDH, GOT, GPT, did not show any change by the premedication of methyl-B<SUB>12</SUB>. 2) Hemorrhage, the damage of blood vessel epithelia and the migration of wondering cells in the testis were reduced markedly by the premedication of methyl-B<SUB>12</SUB>. 3) The increase of Ca contents in the rat testis induced by CdCl<SUB>2</SUB> was also supressed significantly by the premedication of methyl-B<SUB>12</SUB>. These suggest that methyl-B<SUB>12</SUB> has anti-inflammatory effect against the hemorrhagic inflammation in the testis of rat administered CdCl<SUB>2</SUB>.
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