<I>Role of IgG<SUB>4</SUB> antibodies in immediate hypersensitivity</I>
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概要
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The role of IgG<SUB>4</SUB> antibodies in immediate hypersensitivity will be discussed in this paper, both from experimental and clinical point of view. The data described will show that 1) not only IgE but also IgG<SUB>4</SUB> molecules are present on human basophils, 2) IgE-mediated basophil degranulation may be inhibited by passive sensitization with excess amounts of IgG<SUB>4</SUB> antibodies, 3) allergen-specific IgG<SUB>4</SUB> antibodies become prominent upon repeated parenteral stimulation with antigen, such as immunotherapy and bee-stings, in asthmatics and in bee keepers. The overall results suggest that IgG<SUB>4</SUB> antibodies may react as blocking antibodies which produce protective effect during clinical course, in a certain type of allergic disorders. The role of IgG<SUB>4</SUB> antibodies as anaphylactic antibodies will be also briefly discussed.
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