<I>Membrane potential change coupled with the metabolic changes of polymorphonuclear leukocyte stimulated by various stimuli</I>

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Both hyperpolarization and depolarization of cell membrane have been observed in neutrophil exposed to various stimuli. With the techniques for the measurement of membrane potential by using the partition of lipophilic probes, we have found that many of stimuli elicit a depolarization in 30 seconds after stimulation. But the change in membrane potential is unlikely to be involved in the initial triggering process leading to activation of several neutrophil metabolisms, because the collaps of membrane potential has no any special implication in cell activation. These membrane potential change may contribute the orientation or pass through of protein or other substance in membrane and may appear to provide the trigger for stimulation of some membrane bound enzymes.
日本炎症・再生医学会の論文